Pathologic physiology and chemotherapy of Plasmodium berghei
Identifieur interne : 003C30 ( Main/Exploration ); précédent : 003C29; suivant : 003C31Pathologic physiology and chemotherapy of Plasmodium berghei
Auteurs : Chiravat Sadavongvivad [États-Unis] ; Domingo M. Aviado [États-Unis]Source :
- Experimental Parasitology [ 0014-4894 ] ; 1969.
Descripteurs français
- KwdFr :
- Acidose respiratoire (), Alvéoles pulmonaires (anatomopathologie), Animaux, Chloroquine (pharmacologie), Chloroquine (usage thérapeutique), Compliance pulmonaire, Emphysème pulmonaire (étiologie), Paludisme (anatomopathologie), Paludisme (physiopathologie), Paludisme (traitement médicamenteux), Plasmodium (), Poumon (anatomopathologie), Poumon (physiologie), Rats, Souris, Spirométrie, Tests de la fonction respiratoire.
- MESH :
- anatomopathologie : Alvéoles pulmonaires, Paludisme, Poumon.
- pharmacologie : Chloroquine.
- physiologie : Poumon.
- physiopathologie : Paludisme.
- traitement médicamenteux : Paludisme.
- usage thérapeutique : Chloroquine.
- étiologie : Emphysème pulmonaire.
- Acidose respiratoire, Animaux, Compliance pulmonaire, Plasmodium, Rats, Souris, Spirométrie, Tests de la fonction respiratoire.
English descriptors
- KwdEn :
- Acidosis, Respiratory (complications), Animals, Chloroquine (pharmacology), Chloroquine (therapeutic use), Lung (pathology), Lung (physiology), Lung Compliance, Malaria (drug therapy), Malaria (pathology), Malaria (physiopathology), Mice, Plasmodium (drug effects), Pulmonary Alveoli (pathology), Pulmonary Emphysema (etiology), Rats, Respiratory Function Tests, Spirometry.
- MESH :
- chemical , pharmacology : Chloroquine.
- complications : Acidosis, Respiratory.
- drug effects : Plasmodium.
- drug therapy : Malaria.
- etiology : Pulmonary Emphysema.
- pathology : Lung, Malaria, Pulmonary Alveoli.
- physiology : Lung.
- physiopathology : Malaria.
- chemical , therapeutic use : Chloroquine.
- Teeft :
- Alveolar septa, Alveolar walls, Animals, Aviado, Berghei, Body plethysmograph, Body weight, Chemotherapy, Chloroquine, Dissociation curve, Drug resistance, Experimental parasitology, Functional tests, Histological, Histological examination, Histological section, Human malaria, Important difference, Intraperitoneal injection, Lung Compliance, Lung function, Malaria, Malarial, Malarial blood, Malarial infection, Malarial lung, Malarial mice, Malarial mouse, Malarial rats, Mast cells, Mechanical properties, Mice, Mouse, Normal lung, Normal rats, Palecek, Parasitemia, Pathologic physiology, Pathological processes, Percentage parasitemia, Physiology, Plasmodium, Plasmodium berghei, Plasmodium berghei infection, Pulmonary compliance, Pulmonary edema, Pulmonary resistance, Rat, Rats, Resistant strain, Respiratory Function Tests, Respiratory difficulties, Respiratory minute volume, Sadavongvivad, Septum, Significant difference, Simultaneous increase, Sodium pentobarbital, Spirometry, Table measurements litter, Tracheal, Tracheal cannula, Transpulmonary pressure.
Abstract
Abstract: The rats infected with Plasmodium berghei showed the following changes in the lung: (a) Elevation in pulmonary compliance; (b) elevation in pulmonary resistance; (c) increase in respiratory minute volume; (d) increase in functional residual capacity; and (e) disruption of alveolar septa and increase in air space as revealed by histological examination. The latter changes (d and e) indicate emphysematous lesions which may relate to the respiratory difficulties and acidosis appearing just prior to death of the malarial rats. The mice infected with chloroquine-resistant strain of P. berghei show a predominance of nucleated cells in the alveolar septa. The identity of these cells and their relation to the development of drug resistance require investigation.
Url:
DOI: 10.1016/0014-4894(69)90170-2
Affiliations:
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Le document en format XML
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(complications)</term><term>Animals</term><term>Chloroquine (pharmacology)</term><term>Chloroquine (therapeutic use)</term><term>Lung (pathology)</term><term>Lung (physiology)</term><term>Lung Compliance</term><term>Malaria (drug therapy)</term><term>Malaria (pathology)</term><term>Malaria (physiopathology)</term><term>Mice</term><term>Plasmodium (drug effects)</term><term>Pulmonary Alveoli (pathology)</term><term>Pulmonary Emphysema (etiology)</term><term>Rats</term><term>Respiratory Function Tests</term><term>Spirometry</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acidose respiratoire ()</term><term>Alvéoles pulmonaires (anatomopathologie)</term><term>Animaux</term><term>Chloroquine (pharmacologie)</term><term>Chloroquine (usage thérapeutique)</term><term>Compliance pulmonaire</term><term>Emphysème pulmonaire (étiologie)</term><term>Paludisme (anatomopathologie)</term><term>Paludisme (physiopathologie)</term><term>Paludisme (traitement médicamenteux)</term><term>Plasmodium ()</term><term>Poumon (anatomopathologie)</term><term>Poumon (physiologie)</term><term>Rats</term><term>Souris</term><term>Spirométrie</term><term>Tests de la fonction respiratoire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Alvéoles pulmonaires</term><term>Paludisme</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Acidosis, Respiratory</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Plasmodium</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Malaria</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Pulmonary Emphysema</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term><term>Malaria</term><term>Pulmonary Alveoli</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Paludisme</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Malaria</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Paludisme</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Emphysème pulmonaire</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Alveolar septa</term><term>Alveolar walls</term><term>Animals</term><term>Aviado</term><term>Berghei</term><term>Body plethysmograph</term><term>Body weight</term><term>Chemotherapy</term><term>Chloroquine</term><term>Dissociation curve</term><term>Drug resistance</term><term>Experimental parasitology</term><term>Functional tests</term><term>Histological</term><term>Histological examination</term><term>Histological section</term><term>Human malaria</term><term>Important difference</term><term>Intraperitoneal injection</term><term>Lung Compliance</term><term>Lung function</term><term>Malaria</term><term>Malarial</term><term>Malarial blood</term><term>Malarial infection</term><term>Malarial lung</term><term>Malarial mice</term><term>Malarial mouse</term><term>Malarial rats</term><term>Mast cells</term><term>Mechanical properties</term><term>Mice</term><term>Mouse</term><term>Normal lung</term><term>Normal rats</term><term>Palecek</term><term>Parasitemia</term><term>Pathologic physiology</term><term>Pathological processes</term><term>Percentage parasitemia</term><term>Physiology</term><term>Plasmodium</term><term>Plasmodium berghei</term><term>Plasmodium berghei infection</term><term>Pulmonary compliance</term><term>Pulmonary edema</term><term>Pulmonary resistance</term><term>Rat</term><term>Rats</term><term>Resistant strain</term><term>Respiratory Function Tests</term><term>Respiratory difficulties</term><term>Respiratory minute volume</term><term>Sadavongvivad</term><term>Septum</term><term>Significant difference</term><term>Simultaneous increase</term><term>Sodium pentobarbital</term><term>Spirometry</term><term>Table measurements litter</term><term>Tracheal</term><term>Tracheal cannula</term><term>Transpulmonary pressure</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acidose respiratoire</term><term>Animaux</term><term>Compliance pulmonaire</term><term>Plasmodium</term><term>Rats</term><term>Souris</term><term>Spirométrie</term><term>Tests de la fonction respiratoire</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The rats infected with Plasmodium berghei showed the following changes in the lung: (a) Elevation in pulmonary compliance; (b) elevation in pulmonary resistance; (c) increase in respiratory minute volume; (d) increase in functional residual capacity; and (e) disruption of alveolar septa and increase in air space as revealed by histological examination. The latter changes (d and e) indicate emphysematous lesions which may relate to the respiratory difficulties and acidosis appearing just prior to death of the malarial rats. The mice infected with chloroquine-resistant strain of P. berghei show a predominance of nucleated cells in the alveolar septa. The identity of these cells and their relation to the development of drug resistance require investigation.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Sadavongvivad, Chiravat" sort="Sadavongvivad, Chiravat" uniqKey="Sadavongvivad C" first="Chiravat" last="Sadavongvivad">Chiravat Sadavongvivad</name></region><name sortKey="Aviado, Domingo M" sort="Aviado, Domingo M" uniqKey="Aviado D" first="Domingo M." last="Aviado">Domingo M. Aviado</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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